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It does not produce more effective analgesia than the oral route unless the patient cannot use oral medication, or has serious compliance problems. Elderly There have been no specific studies of Valoid in the elderly. The exact mechanism by which cyclizine can prevent or suppress both nausea and vomiting from various causes is unknown. Name of the medicinal product 2. To email a medicine you must sign up and log in. Hepatobiliary disorders Hepatic dysfunction see section 4. Local palliative care guidelines should always be followed when mixing drugs in a syringe driver:.

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Join the discussion on the forums. You may find the End of Life Care article more useful, or one of our other health articles. For instructions on dilution of the medicinal product before administration, see section 6. By mouth, or by intravenous injection For Child 1 month—5 years 0.

Each pack contains 5 or 10 ampoules. Related Treatment Summaries Acute coronary syndromes Antihistamines, allergen immunotherapy and allergic emergencies Nausea and labyrinth disorders Other drugs classified as antihistamines. Agranulocytosis, leucopenia, haemolytic anaemia, thrombocytopenia. Patient Platform Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy.

For the prevention of postoperative nausea and vomiting, administer the first dose by slow intravenous injection 20 minutes before the anticipated end of surgery. Enter medicine name or company Cycliine typing to retrieve search suggestions.

Syringe Drivers. Subcutaneous (SC) drug infusion Syringe Driver | Patient

Because of its anticholinergic activity, cyclizine may enhance the side-effects of other anticholinergic drugs, and may have an additive antimuscarinic action shringe other antimuscarinic drugs, such as atropine and some antidepressants both tricyclics and MAOIs.


Pain is experienced by most patients with advanced cancer.

Last updated on eMC: Sublingual administration is not always easy if the mouth is dry, co-ordination is poor or cognitive function is impaired. Reporting suspected adverse reactions after authorisation of the medicinal product is ssyringe.

Valoid is indicated in adults for the prevention and treatment of nausea and vomiting including: Valoid injection may have a hypotensive effect. There have been reports of abuse of cuclizine, either oral or intravenous, for its euphoric or hallucinatory effects.

Angle closure glaucoma ; depression. It is most frequently used in palliative care particularly cancer carebypassing problems such as: Generally there are few compatibility problems with common two and three drug combinations containing:.

Epilepsy ; cycpizine in children ; may counteract haemodynamic benefits of cycliine ; neuromuscular disorders—increased risk of transient paralysis with intravenous use ; prostatic hypertrophy in adults ; pyloroduodenal obstruction ; severe heart failure—may cause fall in cardiac output and associated increase in heart rate, mean arterial pressure and pulmonary wedge pressure ; susceptibility to angle-closure glaucoma in adults ; urinary retention.

Hypersensitivity to the active substance or to any of the excipients listed in section 6. Marketing authorisation number s 9.

Cyclizine Lactate 50 mg/ml Injection – Summary of Product Characteristics (SmPC) – (eMC)

Other common indications for using a syringe driver in palliative care include the treatment of nausea and vomiting, excessive respiratory secretions, and agitation or restlessness. Breast-feeding Cyclizine is excreted in human milk, however, the amount has not been quantified.


Symptoms of acute toxicity from cyclizine arise from peripheral anticholinergic effects and effects on the central nervous system. Thank you, we just sent a survey email to confirm your preferences. For the prevention of postoperative nausea and vomiting, administer the first dose by slow intravenous injection 20 minutes before the anticipated end syrine surgery.

Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.

General disorders and administration site conditions Not known Asthenia Injection site reactions including vein tracking, erythema, pain, thrombophlebitis and blisters. Dryness of the mouth, nose and throat, constipation, increased gastric ysringe, nausea, vomiting, diarrhoea, stomach pain, loss of appetite. By mouth, or by intravenous injection.

Frequency not known With oral use level of consciousness decreased With parenteral use chills ; consciousness impaired ; pain ; paralysis ; sensation of pressure ; thrombophlebitis.

Cyclizine Lactate 50 mg/ml Solution for Injection

Injection not licensed for use cycljzine children. As with other anticholinergic agents, cyclizine may precipitate incipient glaucoma and it should be used with caution and appropriate monitoring in patients with glaucoma, urinary retention, obstructive disease of the gastrointestinal tract, hepatic disease, pheochromocytoma, hypertension, epilepsy and in males with possible prostatic hypertrophy.

Some of the patients mentioned in these case reports had an underlying neuromuscular disorder see section 4.