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See also Dry mouth , above. Repeated administration of diamorphine may lead to dependence and tolerance developing. Many patients wish to remain at home with their families. Great caution should be exercised in patients with a known tendency or history of drug abuse. Upward titration of the dose of morphine stops when either the pain is relieved or unacceptable adverse effects occur, after which it is necessary to consider alternative measures.

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Alternatives to morphineincluding transdermal buprenorphinetransdermal fentanylhydromorphone hydrochloridemethadone hydrochlorideor oxycodone hydrochlorideshould be initiated by those with experience in palliative care. If treatment continues for more than 24 hours it may be appropriate to use a syringe driver Burne R, Hunt A, Palliative Medicine thorugh, 1, Children and Elderly: Nerve blocks or regional anaesthesia techniques including the use of epidural and intrathecal catheters can be considered when pain is localised to a throigh area.


diamoprhine Diamorphine is a pain killing drug. Show table of contents Hide table of contents 1. This medicine can impair cognitive function and can affect a patient’s ability to drive safely. Oxycodone hydrochloride througg preparations can be given for breakthrough pain. It is important to let them know. Confusion and restlessness Haloperidol has little sedative effect. Benzodiazepines, such as temazepammay be useful. Although drugs can usually be administered by mouth to control the symptoms of advanced cancer, the parenteral route may sometimes be necessary.


It is predominantly a central nervous system depressant but it has stimulant actions resulting in nausea, vomiting and miosis. Bowel colic and excessive respiratory secretions may be reduced by a subcutaneous injection of hyoscine hydrobromidehyoscine butylbromideor glycopyrronium bromide. Pain due to nerve compression may be reduced by a corticosteroid such as dexamethasonewhich ghrough oedema around the tumour, thus throughh compression.

Levomepromazine is used as an antiemetic; it is given by mouth or by subcutaneous injection at bedtime. Marketing authorisation number s 9.

Restlessness and confusion may require treatment with an antipsychotic, e. A corticosteroid such as dexamethasone may help, temporarily, if there is an obstruction due to tumour. The infusion is discontinued when the first oral dose of morphine is given.

It can be very harmful to just stop taking diamorphine. Cyclizine is given by ysringe. Diamorphine should be administered with care to patients with head injuries as there is an increased risk of respiratory depression which may lead to elevation of CSF pressure.

Diamorphine | Cancer in general | Cancer Research UK

In severe chronic cholestasis, absorption of vitamin K may be impaired; either parenteral or water-soluble oral vitamin K see phytomenadione and menadiol sodium phosphate should be considered. This information is intended for use by health professionals.


Respiratory depression and obstructive airways disease. Sign Up Log In Cancel.

This site uses cookies. A suitable laxative should be prescribed routinely. Because of these risks, concomitant prescribing with these sedative medicines should be reserved for patients for whom alternative treatment options are not possible.

Alcohol may enhance diamorphinw sedative and hypotensive effects of diamorphine. If you become drowsy after having diamorphine for a while, it may mean that you need to lower your dose. Anorexia may be helped by prednisolone or dexamethasone.

The reconstituted lyophilisate is a clear solution. Use with caution in patients with toxic psychosis, CNS depression, myxoedema, prostatic hypertrophy or urethral stricture, kyphoscoliosis, acute alcoholism, delirium tremens, severe inflammatory or obstructive bowel disorders, adrenal insufficiency or severe diarrhoea.

Haloperidol and levomepromazine can both be given as a subcutaneous infusion but sedation can limit the dose of levomepromazine.